FerAppease was developed by FERA Diagnostics & Biologicals to reduce stress and improve welfare and performance in both beef and dairy cattle.

The active ingredient of FerAppease is a synthetic analogue of the Maternal Bovine Appeasing Substance (MBAS). MBAS is naturally secreted by the sebaceous gland located on the skin of the mammary gland with the unique function of inducing an appeasing effect.

FerAppease is topically applied to cattle above the muzzle and in the divot behind the poll.

The active ingredient, a synthetic analogue of the Maternal Bovine Appeasing Substance (MBAS) is assimilated by the vomeronasal gland located in the nose of the animals.

The MBAS stimulation of the vomeronasal gland desensitizes regions of the amygdala and the hypothalamus, dramatically decreasing threat perception and its downstream stress consequences.

FerAppease should only be used on healthy cattle, applied topically above the muzzle and in the divot behind the poll.

FerAppease can and should be used every time cattle are exposed to management and physiological stressors where suppression of threat perception is desirable including:

• weaning
• dehorning
• castration
• branding
• transportation
• commingling
• vaccination
• parturition
• interruption of lactation (dry off)
• breeding

> 200 lb: Apply 5 mL of FerAppease behind the poll and a second 5 mL application to the skin above the muzzle.

< 200 lb: Apply 2.5 mL of FerAppease behind the poll and a second 2.5 mL application to the skin above the muzzle.

Behavior modulation and stress mitigation starts to take place immediately after FerAppease is applied to cattle.

No, FerAppease does not require a veterinarian's prescription or a Veterinary Feed Directive plan for use in beef or dairy cattle.

> 200 lb - 10 mL dose: $3.00 per head

< 200 lb - 5 mL dose: $1.50 per head

FerAppease is considered safe for use in cattle, with no known side effects reported.

No, there is no meat or milk withdrawal period after treating cattle with FerAppease.

FerAppease is an oil-based product, so it should be applied to dry cattle. For best results, allow at least 30 minutes for FerAppease to absorb into the skin before cattle get wet.

One application of FerAppease is effective for 14 days. Because most stressful events in cattle last less than two weeks, a single treatment supports them throughout the entire challenge period.

If cattle are being run through the chute after the 14-day period for any reason, such as revaccinating, studies have shown there are benefits to reapplying FerAppease at this time.

FerAppease MBAS has a shelf life of two years. It can be stored safely until its expiration date.

FerAppease should be kept at controlled room temperature between 10–30℃ (50–86℉). Do not refrigerate or freeze.

No. FerAppease is a proprietary product developed by FERA Diagnostics & Biologicals.

Yes, the FerAppease Pour-On Gun is a specialized applicator designed to administer FerAppease 300 mL solutions to cattle, allowing for precise, controlled dosing directly onto the animals’ skin. The Line Fed Pour-On Applicator is also available for 1 L bottles of FerAppease.

FerAppease MBAS is available in three convenient sizes: 300 mL bottle, 1 L bottle, and a 4 L jug

Yes. FerAppease is protected under U.S. Patent No. 12,310,937, with additional patents pending. The FerAppease® trademark is registered under No. 7,084,410 as of June 20, 2023.

Yes. To request the complete bovine study data for FerAppease, please email us at inquiry@feraah.com

FerAppease was first developed by FERA Diagnostics & Biologicals to reduce stress and enhance welfare and performance in cattle. Building on that success, it is now also used in swine, where it delivers proven stress‑reduction benefits that support pig welfare and productivity.

The active ingredient of FerAppease is a synthetic analogue of the Maternal Swine Appeasing Substance (MSAS). MSAS is naturally secreted by the sebaceous gland located on the skin of the mammary gland with the unique function of inducing an appeasing effect.

FerAppease is topically applied to pigs skin above the muzzle to the forehead.

The active ingredient, a synthetic analogue of the Maternal Swine Appeasing Substance (MSAS) is assimilated by the vomeronasal gland located in the nose of the animals.

The MSAS stimulation of the vomeronasal gland desensitizes regions of the amygdala and the hypothalamus, dramatically decreasing threat perception and its downstream stress consequences.

FerAppease should only be used on healthy pigs, applied topically to the skin above the muzzle to the forehead.

FerAppease can and should be used every time animals are exposed to management and physiological stressors where suppression of threat perception is desirable including:

• weaning
• castration
• vaccination
• processing
• commingling
• transportation
• farrowing
• interruption of lactation (dry off)
• breeding
• heat stress mitigation
• show training
• show days

For piglets apply 3 mL of FerAppease from the skin above the muzzle to the forehead.

For adult pigs apply 10 mL from the skin above the muzzle to the forehead.

Behavior modulation and stress mitigation starts to take place immediately after FerAppease is applied to pigs.

No, FerAppease does not require a veterinarian's prescription or a Veterinary Feed Directive plan for use in pigs.

Adult Pigs: $0.68 cents per head

Piglets: $0.20 cents per head

Show Pigs: $1.67 per 5 mL dose or $3.33 per 10 mL dose

FerAppease is considered safe for use in swine, with no known side effects reported.

No, there is no meat or milk withdrawal period after treating pigs with FerAppease.

FerAppease is an oil-based product, so it should be applied to dry pigs. For best results, allow at least 30 minutes for FerAppease to absorb into the skin before pigs get wet.

One application of FerAppease is effective for 14 days. Because most stressful events in swine last less than two weeks, a single treatment supports them throughout the entire challenge period.

If swine are being run through the chute after the 14-day period for any reason, such as revaccinating, studies have shown there are benefits to reapplying FerAppease at this time.

FerAppease MSAS has a shelf life of two years. It can be stored safely until its expiration date.

FerAppease should be kept at controlled room temperature between 10–30℃ (50–86℉). Do not refrigerate or freeze.

No. FerAppease is a proprietary product developed by FERA Diagnostics & Biologicals.

Yes, the FerAppease Pour-On Gun is a specialized applicator designed to administer FerAppease solutions to swine, allowing for precise, controlled dosing directly onto the animals’ skin.

FerAppease MSAS is available in two convenient sizes: a 300 mL bottle and 4 L jugs

Yes. FerAppease is protected under U.S. Patent No. 12,310,937, with additional patents pending. The FerAppease® trademark is registered under No. 7,084,410 as of June 20, 2023.

Yes. To request the complete swine study data for FerAppease, please email us at inquiry@feraah.com

FerAppease® MSRAS (Maternal Small Ruminant Appeasing Substance) is a topical analogue of the small ruminant appeasing substance designed for use in healthy sheep and goats. FerAppease helps support animal welfare and stress management during breeding, weaning, transportation, handling, and other stressful events.

FerAppease MSRAS uses an analogue of the maternal small ruminant appeasing substance to help sheep and goats respond to stressful situations. It is designed to support animal welfare during routine management practices and anticipated stress events.

FerAppease offers species-specific formulations designed to support animal welfare and stress management. FerAppease MSRAS (Maternal Small Ruminant Appeasing Substance) is formulated for sheep and goats, FerAppease MBAS (Maternal Bovine Appeasing Substance) is formulated for cattle, and FerAppease MSAS (Maternal Swine Appeasing Substance) is formulated for pigs. Each product uses an analogue of the respective species' maternal appeasing substance to help animals respond to stressful events.

Yes! FerAppease MSRAS is extremely safe when used as directed in healthy sheep and goats. It is non-invasive and intended for topical application only—it should never be injected. Always shake the bottle well before use and follow the recommended dosage based on the animal’s body weight.

FerAppease MSRAS is an analogue of the maternal small ruminant appeasing substance, not a conventional sedative or tranquilizer. It is designed to support the animal's response to stress rather than induce sedation.

FerAppease MSRAS is simple to apply topically. Always shake the bottle thoroughly before application. Using the dosing dispenser, apply the calculated dose topically to the two designated skin sites: above the nose and to the poll (top of the head). FerAppease is strictly for topical use and must never be injected.

The recommended dosage of FerAppease MSRAS depends on the animal's body weight. For sheep and goats weighing under 88 lb (40 kg), apply 2.5 mL above the nose and 2.5 mL to the poll, for a total of 5 mL per animal. For animals weighing over 88 lb (40 kg), apply 5 mL above the nose and 5 mL to the poll, for a total of 10 mL per animal. Shake well before use. FerAppease is for topical application only and should not be injected.

One 300 mL bottle of FerAppease MSRAS can treat up to 60 young sheep or goats weighing under 88 lb, or up to 30 adult sheep or goats weighing over 88 lb, based on the recommended application amounts.

FerAppease MSRAS can be reapplied after 14 days if needed. Application timing should be based on anticipated stress events and the animal management protocol.

FerAppease MSRAS should be applied to two specific anatomical sites: topically above the nose (nuzzle/snout area) and on the poll (the top of the head between the ears). The total recommended dose for the animal is divided equally between these two locations.

Yes. FerAppease MSRAS can be incorporated into sheep and goat breeding management protocols to help address stress associated with reproductive procedures, animal handling, and management changes.

FerAppease MSRAS can be applied to rams and bucks upon arrival or during commingling to help manage stress associated with transportation, introduction to new groups, and changes in their environment.

Yes. FerAppease MSRAS can be incorporated into laparoscopic artificial insemination (LAI) protocols for sheep and goats. For donor females, application may occur 30 to 60 days before the procedure or at LAI. Females undergoing LAI only may receive FerAppease at the time of insemination.

Yes. FerAppease MSRAS can be used in sheep and goat embryo transfer programs as part of reproductive stress management. Recipient females may receive FerAppease following embryo transfer, according to the reproductive management protocol.

For sheep and goats undergoing ovum pickup (OPU) as part of an in vitro fertilization (IVF) program, FerAppease MSRAS may be applied 24 to 48 hours before OPU or as directed by the reproductive management protocol.

Absolutely. Weaning is one of the most stressful events in a young animal's life. FerAppease MSRAS helps mitigate weaning stress caused by maternal separation, dietary changes, new housing, and social regrouping—helping lambs and kids adapt faster, stay healthier, and maintain weight gain and performance.

Yes. FerAppease MSRAS can be applied to lambs and kids following routine processing procedures to support their response to handling-related stress.

Yes. FerAppease MSRAS can be applied before shipping or travel to help sheep and goats manage transportation-related stress, including handling, loading, and changes in their environment.

Yes. FerAppease MSRAS can be used in show lambs and goats to support stress management during handling, transportation, and participation in livestock shows or exhibitions. Apply before shipping or travel according to product directions.

Yes. FerAppease MSRAS can be applied following lambing or kidding to help manage stress in fractious or difficult-to-handle ewes and does. It should be used as part of appropriate postpartum animal management and veterinary care.

FerAppease MSRAS can be incorporated into sheep and goat management programs during anticipated stress events, including handling, commingling, weaning, transportation, breeding procedures, and environmental changes. Application is recommended before the anticipated stress event when possible.

No. FerAppease MSRAS has zero withdrawal time for both meat and milk. No slaughter or milk withdrawal period is required when used according to product directions.

Yes. FerAppease MSRAS can be used in lactating dairy goats and sheep to support stress management during routine dairy operations, including milking, handling, separation from offspring, and changes in housing or social groups. FerAppease has zero milk withdrawal time, allowing dairy animals to remain in milk production without interruption when used according to product directions.

No. FerAppease MSRAS does not require refrigeration. Store the product between 50°F and 86°F (10°C to 30°C).

FerAppease MSRAS for sheep and goats is available in a 300 mL bottle. Each bottle provides up to 60 applications for animals under 88 lb or 30 applications for animals over 88 lb.

No. FerAppease MSRAS for sheep and goats is a non-prescription product and does not require a veterinary prescription for purchase or use. It can be incorporated into routine flock and herd management programs to help support animal welfare and stress management during anticipated stressful events.

Yes. FerAppease is protected under U.S. Patent No. 12,310,937, with additional patents pending. The FerAppease® trademark is registered under No. 7,084,410 as of June 20, 2023.

Yes. To request the complete small ruminants study data for FerAppease, please email us at inquiry@feraah.com